| Title : Hopeahainol A: an acetylcholinesterase inhibitor from Hopea hainanensis - Ge_2008_Chemistry_14_376 |
| Author(s) : Ge HM , Zhu CH , Shi da H , Zhang LD , Xie DQ , Yang J , Ng SW , Tan RX |
| Ref : Chemistry , 14 :376 , 2008 |
|
Abstract :
A phytochemical study of Hopea hainanensis has led to the isolation of three new polyphenols and one known compound. The most important of these compounds are hopeahainols A (2) and B (3), which contain an unprecedented carbon skeleton. The structures were elucidated by analysis of the spectroscopic data including single-crystal X-ray spectroscopy and computational methods. Hopeahainol A was an acetylcholinesterase inhibitor with an IC50 value of 4.33 microM, which is comparable to that of huperzine A, a presently prescribed drug for the treatment of Alzheimer, while other similar structures were inactive. This observation was complemented by a 3D interaction model of the inhibitor with active sites. |
| PubMedSearch : Ge_2008_Chemistry_14_376 |
| PubMedID: 17943703 |
| Inhibitor | Hopeahainol-A |
Ge HM, Zhu CH, Shi da H, Zhang LD, Xie DQ, Yang J, Ng SW, Tan RX (2008)
Hopeahainol A: an acetylcholinesterase inhibitor from Hopea hainanensis
Chemistry
14 :376
Ge HM, Zhu CH, Shi da H, Zhang LD, Xie DQ, Yang J, Ng SW, Tan RX (2008)
Chemistry
14 :376