Gelerstein_1988_Dev.Biol_127_25

Reference

Title : Is a decrease in cyclic AMP a necessary and sufficient signal for maturation of amphibian oocytes? - Gelerstein_1988_Dev.Biol_127_25
Author(s) : Gelerstein S , Shapira H , Dascal N , Yekuel R , Oron Y
Ref : Developmental Biology , 127 :25 , 1988
Abstract :

Acetylcholine rapidly lowered the intracellular levels of cyclic AMP in stage 5 and 6 Xenopus laevis oocytes. Acetylcholine alone did not induce oocyte maturation, though it did accelerate maturation induced by progesterone. The effect of acetylcholine on oocyte maturation was independent of extracellular calcium concentration. Adenosine increased cyclic AMP and abolished the progesterone-induced decrease in cyclic AMP levels in follicles and in denuded oocytes. This effect of adenosine was blocked by the Ra purinergic receptor antagonist, theophylline. Despite those effects, adenosine alone induced maturation in stage 6 oocytes and accelerated progesterone-induced maturation in both stage 5 and 6 cells. Adenosine also induced a significant increase in the rate of 45Ca efflux from oocytes in the presence and the absence of external calcium. We suggest that the activation of cell surface receptors involved in the release of calcium from cellular stores may induce or accelerate oocyte maturation independently of small changes in intracellular cyclic AMP concentration.

PubMedSearch : Gelerstein_1988_Dev.Biol_127_25
PubMedID: 2834247

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Citations formats

Gelerstein S, Shapira H, Dascal N, Yekuel R, Oron Y (1988)
Is a decrease in cyclic AMP a necessary and sufficient signal for maturation of amphibian oocytes?
Developmental Biology 127 :25

Gelerstein S, Shapira H, Dascal N, Yekuel R, Oron Y (1988)
Developmental Biology 127 :25