| Title : Molecular decoys: ligand-binding recombinant proteins protect mice from curarimimetic neurotoxins - Gershoni_1988_Proc.Natl.Acad.Sci.U.S.A_85_4087 |
| Author(s) : Gershoni JM , Aronheim A |
| Ref : Proc Natl Acad Sci U S A , 85 :4087 , 1988 |
|
Abstract :
Mimic ligand-binding sites of the nicotinic acetylcholine receptor bind d-tubocurarine and alpha-bungarotoxin in vitro. Injection of such binding sites into mice could act as molecular decoys in vivo, providing protection against toxic ligands. This hypothesis of molecular "decoyance" has been tested in greater than 250 mice. Bacterially produced cholinergic binding sites provided a 2-fold increase in the survival rate of animals challenged with curarimimetic neurotoxins. Possible considerations for decoy designs and their applications are discussed. |
| PubMedSearch : Gershoni_1988_Proc.Natl.Acad.Sci.U.S.A_85_4087 |
| PubMedID: 3375254 |
Gershoni JM, Aronheim A (1988)
Molecular decoys: ligand-binding recombinant proteins protect mice from curarimimetic neurotoxins
Proc Natl Acad Sci U S A
85 :4087
Gershoni JM, Aronheim A (1988)
Proc Natl Acad Sci U S A
85 :4087