Geula_2004_Drugs.Today.(Barc)_40_711

Reference

Title : Butyrylcholinesterase, cholinergic neurotransmission and the pathology of Alzheimer's disease - Geula_2004_Drugs.Today.(Barc)_40_711
Author(s) : Geula C , Darvesh S
Ref : Drugs Today (Barc) , 40 :711 , 2004
Abstract :

Butyrylcholinesterase is a serine hydrolase biochemically related to the cholinergic enzyme acetylcholinesterase. It is capable of hydrolyzing esters of choline. Butyrylcholinesterase has unique enzymatic properties and is widely distributed in the nervous system, raising the possibility of its involvement in neural function. In particular, recent evidence indicates that along with acetylcholinesterase, butyrylcholinesterase catalyzes the hydrolysis of acetylcholine, and thus serves as a co-regulator of cholinergic transmission. Accumulating evidence also indicates that butyrylcholinesterase is likely to be involved in neurodegenerative disorders such as Alzheimer's disease. Therefore, inhibition of butyrylcholinesterase will not only lead to enhanced cholinergic transmission but also has the potential to interfere with the disease process in Alzheimer's disease and other dementing disorders.

PubMedSearch : Geula_2004_Drugs.Today.(Barc)_40_711
PubMedID: 15510242

Related information

Citations formats

Geula C, Darvesh S (2004)
Butyrylcholinesterase, cholinergic neurotransmission and the pathology of Alzheimer's disease
Drugs Today (Barc) 40 :711

Geula C, Darvesh S (2004)
Drugs Today (Barc) 40 :711