Ghatreh_2012_Iran.J.Public.Health_41_59

BACKGROUND The T allele of the hepatic lipase HL C-514T polymorphism was previously found to be associated with lower plasma HL activity Here we examined the association between this polymorphism and plasma HDL-cholesterol concentrations in patients with coronary arteries stenosis METHODS We studied 342 subjects undergoing coronary angiography in two groups of non CAD n=146 and CAD n=196 514C-->T polymorphism was determined using polymerase chain reaction and restriction fragment length polymorphism PCR-RFLP RESULTS After adjustment for age smoking and body mass index HDL-cholesterol concentrations were significantly higher in men with the C/T&T/T genotype than those with the C/C genotype(mean 38.6 and 34.7 respectively P=0.01 The frequency of T allele in non CAD was 0.136 and 0.226 in female and male respectively and 0.170 and 0.223 for female and male in CAD subjects There was no difference in T allele frequency in CAD and none CAD groups in male and female P=0.466 and 0.722 respectively CONCLUSION 514C-->T of LIPC gene have a positive effect on HDL-C concentration especially in male gender However no difference was determined in frequency of T allele between CAD and normal arteries subjects.