| Title : Syntheses and spectroscopic characterization of some phosphoramidates as reversible inhibitors of human acetylcholinesterase and determination of their potency - Gholivand_2006_J.Enzyme.Inhib.Med.Chem_21_31 |
| Author(s) : Gholivand K , Shariatinia Z , Khajeh K , Naderimanesh H |
| Ref : J Enzyme Inhib Med Chem , 21 :31 , 2006 |
|
Abstract :
The ability of phosphoramidates Me2NP(O)(Cl)(p-NHC6H4NO2) 1, Me2NP(O)(p-NHC6H4NO2)2 2, (CH3C6H4O-p)P(O)(p-NHC6H4NO2)2 3 and (CH3C6H40-p)2P(O)(p-NHC6H4NO2) 4 to inhibit human acetylcholinesterase (hAChE) has been evaluated by a modified Ellman's method and spectrophotometric measurements. Results showed that compounds 1 and 2 do not have any inhibitory potency, whereas compounds 3 and 4 were reversible mixed inhibitors. The IC50 values for inhibitors 3 and 4 were 0.143 and 0.581 mM, respectively. The previously unknown compounds 3 and 4 were synthesized and characterized by 1H, 13C, 31P NMR and IR spectroscopy and elemental analysis. |
| PubMedSearch : Gholivand_2006_J.Enzyme.Inhib.Med.Chem_21_31 |
| PubMedID: 16570502 |
Gholivand K, Shariatinia Z, Khajeh K, Naderimanesh H (2006)
Syntheses and spectroscopic characterization of some phosphoramidates as reversible inhibitors of human acetylcholinesterase and determination of their potency
J Enzyme Inhib Med Chem
21 :31
Gholivand K, Shariatinia Z, Khajeh K, Naderimanesh H (2006)
J Enzyme Inhib Med Chem
21 :31