| Title : Role of the M1 receptor in regulating circadian rhythms - Gillette_2001_Life.Sci_68(22-23)_2467 |
| Author(s) : Gillette MU , Buchanan GF , Artinian L , Hamilton SE , Nathanson NM , Liu C |
| Ref : Life Sciences , 68 :2467 , 2001 |
|
Abstract :
Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms. |
| PubMedSearch : Gillette_2001_Life.Sci_68(22-23)_2467 |
| PubMedID: 11392614 |
Gillette MU, Buchanan GF, Artinian L, Hamilton SE, Nathanson NM, Liu C (2001)
Role of the M1 receptor in regulating circadian rhythms
Life Sciences
68 :2467
Gillette MU, Buchanan GF, Artinian L, Hamilton SE, Nathanson NM, Liu C (2001)
Life Sciences
68 :2467