Gnocchi_2023_Environ.Toxicol.Pharmacol__104124

The present study aimed to evaluate the toxicity of Mn (6.65mg/L) at different exposure times (96h, 7, 14, and 21 days) and evaluate its possible toxic effects on the fish Astyanax lacustris through multi-biomarkers and the maximum critical temperature (CT Max). The results show an increase in the Mn accumulation (liver and gills) with increasing exposure time. The glutathione S-transferase (GST) activity showed differences in the group exposed to Mn for 96h compared to the group exposed for 21 days. The acetylcholinesterase (AChE) activity increased in the fish exposed for 7 days compared to the control group. On the other hand, no genotoxic changes were observed. The CT Max showed that the loss of equilibrium of 50% of the fish occurs at a temperature of 39C, with and without the Mn presence. Furthermore, the catalase gene expression (oxidative stress) did not show alterations.