| Title : In vitro inhibition effect of some coumarin compounds on purified human serum paraoxonase 1 (PON1) - Gokce_2016_J.Enzyme.Inhib.Med.Chem_31_534 |
| Author(s) : Gokce B , Gencer N , Arslan O , Karatas MO , Alici B |
| Ref : J Enzyme Inhib Med Chem , 31 :534 , 2016 |
|
Abstract :
Human serum paraoxonase 1 (PON1; EC 3.1.8.1) is a high-density lipoprotein associated, calcium-dependent enzyme that hydrolyses aromatic esters, organophosphates and lactones and can protect the low-density lipoprotein against oxidation. In this study, in vitro effect of some hydroxy and dihydroxy ionic coumarin derivatives (1-20) on purified PON1 activity was investigated. Among these compounds, derivatives 11-20 are water soluble. In investigated compounds, compounds 6 and 13 were found the most active (IC50 = 35 and 34 microM) for PON1, respectively. The present study has demonstrated that PON1 activity is very highly sensitive to studied coumarin derivatives. |
| PubMedSearch : Gokce_2016_J.Enzyme.Inhib.Med.Chem_31_534 |
| PubMedID: 25982292 |
Gokce B, Gencer N, Arslan O, Karatas MO, Alici B (2016)
In vitro inhibition effect of some coumarin compounds on purified human serum paraoxonase 1 (PON1)
J Enzyme Inhib Med Chem
31 :534
Gokce B, Gencer N, Arslan O, Karatas MO, Alici B (2016)
J Enzyme Inhib Med Chem
31 :534