Goldman_1988_Neuron_1_329

Reference

Title : Acetylcholine receptor alpha-, beta-, gamma-, and delta-subunit mRNA levels are regulated by muscle activity - Goldman_1988_Neuron_1_329
Author(s) : Goldman D , Brenner HR , Heinemann S
Ref : Neuron , 1 :329 , 1988
Abstract :

Denervation of adult skeletal muscle results in increased sensitivity to acetylcholine in extrajunctional regions of the muscle fiber. This increase in acetylcholine sensitivity is accompanied by a large increase in the level of mRNAs coding for the alpha-, beta-, gamma-, and delta-subunits of the acetylcholine receptor. To determine whether muscle activity is sufficient to regulate expression of extrajunctional acetylcholine receptor mRNA levels, denervated muscles were stimulated with extracellular electrodes. Direct stimulation of denervated muscle suppresses both the increase in extrajunctional acetylcholine sensitivity and the expression of mRNA encoding the alpha-, beta-, gamma-, and delta-subunits of the acetylcholine receptor. These results show that muscle activity regulates the level of extrajunctional acetylcholine receptors by regulating the expression of their mRNAs.

PubMedSearch : Goldman_1988_Neuron_1_329
PubMedID: 3272739

Related information

Citations formats

Goldman D, Brenner HR, Heinemann S (1988)
Acetylcholine receptor alpha-, beta-, gamma-, and delta-subunit mRNA levels are regulated by muscle activity
Neuron 1 :329

Goldman D, Brenner HR, Heinemann S (1988)
Neuron 1 :329