Gomez_2015_Eur.J.Neurosci_41_109

Reference

Title : Effects of environmental enrichment on ERK1\/2 phosphorylation in the rat prefrontal cortex following nicotine-induced sensitization or nicotine self-administration - Gomez_2015_Eur.J.Neurosci_41_109
Author(s) : Gomez AM , Sun WL , Midde NM , Harrod SB , Zhu J
Ref : European Journal of Neuroscience , 41 :109 , 2015
Abstract :

Rats raised in an enriched condition (EC) exhibit alterations in the neurobiological and behavioral response to nicotine compared with rats reared in an impoverished condition (IC) or a standard condition (SC). The current study determined whether environmental enrichment differentially regulates extracellular signal-regulated kinase1/2 (ERK1/2) activity in the prefrontal cortex in rats following nicotine sensitization or nicotine self-administration. Under the saline control condition, EC rats displayed diminished baseline activity and greater sensitization to repeated administration of nicotine compared with IC and SC rats. After repeated saline injections, the basal levels of phosphorylated ERK1/2 (pERK1/2) were higher in EC compared with IC and SC rats, which was negatively correlated with their respective baseline activities. Repeated nicotine (0.35 mg/kg) injections induced pERK1/2 to similar levels in SC and IC rats; however, the induction of pERK1/2 in EC rats by nicotine was not significantly different from saline controls, owing to their high baseline. In the self-administration paradigm, EC rats self-administered less nicotine (0.03 mg/kg/infusion) relative to IC or SC rats on a fixed ratio-1 schedule of reinforcement. Accordingly, no differences in pERK1/2 were found between EC and IC rats self-administering saline, whereas nicotine self-administration resulted in an increase in pERK1/2 in IC rats but not in EC rats. Furthermore, the levels of pERK1/2 in EC and IC rats were positively correlated with their respective total number of nicotine infusions. Thus, these findings suggest that environmental enrichment alters the basal and nicotine-mediated pERK1/2, which may contribute to enrichment-induced behavioral alterations in response to nicotine.

PubMedSearch : Gomez_2015_Eur.J.Neurosci_41_109
PubMedID: 25328101

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Citations formats

Gomez AM, Sun WL, Midde NM, Harrod SB, Zhu J (2015)
Effects of environmental enrichment on ERK1\/2 phosphorylation in the rat prefrontal cortex following nicotine-induced sensitization or nicotine self-administration
European Journal of Neuroscience 41 :109

Gomez AM, Sun WL, Midde NM, Harrod SB, Zhu J (2015)
European Journal of Neuroscience 41 :109