| Title : Acetylcholine operated ion channel and alpha-bungarotoxin binding site in a human neuroblastoma cell line reside on different molecules - Gotti_1986_Biochem.Biophys.Res.Commun_137_1141 |
| Author(s) : Gotti C , Wanke E , Sher E , Fornasari D , Cabrini D , Clementi F |
| Ref : Biochemical & Biophysical Research Communications , 137 :1141 , 1986 |
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Abstract :
In neurons, alpha-bungarotoxin is often associated with nicotinic receptor but does not always block the acetylcholine operated channel. In a human neuroblastoma cell line, IMR 32, we have demonstrated a large number of alpha-Bungarotoxin binding sites (2640 per cell in non differentiated cells and 4660 per cell in differentiated cells) in presence of 0 to 4 Acetylcholine activated-channels per cell. This neuronal cell line promises to be an useful model for the study of structure and function of the alpha-Bungarotoxin binding site not related to the nicotinic receptor. |
| PubMedSearch : Gotti_1986_Biochem.Biophys.Res.Commun_137_1141 |
| PubMedID: 2425806 |
Gotti C, Wanke E, Sher E, Fornasari D, Cabrini D, Clementi F (1986)
Acetylcholine operated ion channel and alpha-bungarotoxin binding site in a human neuroblastoma cell line reside on different molecules
Biochemical & Biophysical Research Communications
137 :1141
Gotti C, Wanke E, Sher E, Fornasari D, Cabrini D, Clementi F (1986)
Biochemical & Biophysical Research Communications
137 :1141