| Title : Development of concepts of etiology, pathogenesis and treatment of pemphigus vulgaris based on the hypothesis of atavistic origin of the disease - Grando_1991_Med.Hypotheses_36_43 |
| Author(s) : Grando SA |
| Ref : Med Hypotheses , 36 :43 , 1991 |
|
Abstract :
Atavistically dependent expression of pemphigus vulgaris 'immune' antigen (PVIA) on the human epidermocyte surface is hypothetically the key factor of autoimmune aggression onset in pemphigus patients. Normal epidermocytes can express PVIA in response to a putative factor of 'sheding' as well as to certain biologic, chemical and physical effects. Taking into account the fact that the antibodies against 'shedding' factor carry out the function of anti-idiotypic ones, they can be used as blocking antibodies in treatment of pemphigus vulgaris. |
| PubMedSearch : Grando_1991_Med.Hypotheses_36_43 |
| PubMedID: 1766414 |
Grando SA (1991)
Development of concepts of etiology, pathogenesis and treatment of pemphigus vulgaris based on the hypothesis of atavistic origin of the disease
Med Hypotheses
36 :43
Grando SA (1991)
Med Hypotheses
36 :43