Title : Slow axonal transport of neurofilament proteins: impairment of beta,beta'-iminodipropionitrile administration - Griffin_1978_Science_202_633 |
Author(s) : Griffin JW , Hoffman PN , Clark AW , Carroll PT , Price DL |
Ref : Science , 202 :633 , 1978 |
Abstract :
beta,beta'-Iminodipropionitrile (IDPN) administration prevented normal slow axonal transport of [35S]methionine- or [3H]leucine-labeled proteins in rat sciatic motor axons. Ultrastructural and electrophoretic studies showed that the neurofilament triplet proteins in particular were retained within the initial 5 millimeters of the axons, resulting in neurofilament-filled axonal swellings. Fast anterograde and retrograde axonal transport were not affected. The IDPN thus selectively impaired slow axonal transport. The neurofibrillary pathology in this model is the result of the defective slow transport of neurofilaments. |
PubMedSearch : Griffin_1978_Science_202_633 |
PubMedID: 81524 |
Griffin JW, Hoffman PN, Clark AW, Carroll PT, Price DL (1978)
Slow axonal transport of neurofilament proteins: impairment of beta,beta'-iminodipropionitrile administration
Science
202 :633
Griffin JW, Hoffman PN, Clark AW, Carroll PT, Price DL (1978)
Science
202 :633