| Title : Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block - Grove_2002_Bioorg.Med.Chem.Lett_12_193 |
| Author(s) : Grove SJ , Kaur J , Muir AW , Pow E , Tarver GJ , Zhang MQ |
| Ref : Bioorganic & Medicinal Chemistry Lett , 12 :193 , 2002 |
|
Abstract :
A series of oxyanilinium-based AChE inhibitors have been synthesised and tested for the reversal of vecuronium-induced neuromuscular block Several compounds for example 2-hydroxy and 2-methoxy-N,N-dimethyl-N-allylanilinium bromide 3 and 6 showed comparable reversal potencies to edrophonium and clean in vivo cardiovascular profiles |
| PubMedSearch : Grove_2002_Bioorg.Med.Chem.Lett_12_193 |
| PubMedID: 11755352 |
Grove SJ, Kaur J, Muir AW, Pow E, Tarver GJ, Zhang MQ (2002)
Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block
Bioorganic & Medicinal Chemistry Lett
12 :193
Grove SJ, Kaur J, Muir AW, Pow E, Tarver GJ, Zhang MQ (2002)
Bioorganic & Medicinal Chemistry Lett
12 :193