Grove_2012_Obesity.(Silver.Spring)_20_2311

Reference

Title : (-)-Epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice - Grove_2012_Obesity.(Silver.Spring)_20_2311
Author(s) : Grove KA , Sae-tan S , Kennett MJ , Lambert JD
Ref : Obesity (Silver Spring) , 20 :2311 , 2012
Abstract :

Tea (Camellia sinensis, Theaceae) has been shown to have obesity preventive effects in laboratory studies. We hypothesized that dietary epigallocatechin-3-gallate (EGCG) could reverse metabolic syndrome in high fat-fed obese C57bl/6J mice, and that these effects were related to inhibition of pancreatic lipase (PL). Following treatment with 0.32% EGCG for 6 weeks, a 44% decrease in body weight (BW) gain in high fat-fed, obese mice (P < 0.01) was observed compared to controls. EGCG treatment increased fecal lipid content by 29.4% (P < 0.05) compared to high fat-fed control, whereas in vitro, EGCG dose-dependently inhibited PL (IC(50) = 7.5 micromol/l) in a noncompetitive manner with respect to substrate concentration. (-)-Epicatechin-3-gallate exhibited similar inhibitory activity, whereas the nonester-containing (-)-epigallocatechin did not. In conclusion, EGCG supplementation reduced final BW and BW gain in obese mice, and some of these effects may be due to inhibition of PL by EGCG.

PubMedSearch : Grove_2012_Obesity.(Silver.Spring)_20_2311
PubMedID: 21633405
Gene_locus related to this paper: human-PNLIP

Citations formats

Grove KA, Sae-tan S, Kennett MJ, Lambert JD (2012)
(-)-Epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice
Obesity (Silver Spring) 20 :2311

Grove KA, Sae-tan S, Kennett MJ, Lambert JD (2012)
Obesity (Silver Spring) 20 :2311