| Title : Effect of Bariatric Surgery on Serum Enzyme Status in Obese Patients - Guan_2020_Obes.Surg__ |
| Author(s) : Guan B , Chen Y , Chong TH , Peng J , Mak TK , Wang C , Yang J |
| Ref : Obes Surg , : , 2020 |
| Abstract : BACKGROUND: Scarce data exists about serum enzyme in bariatric patients. We attempted to evaluate serum enzyme status in patients receiving Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) and to identify related predictors. METHODS: We retrospectively reviewed the patients receiving RYGB and SG in our center from January 2013 to January 2018. Anthropometric data and serum enzyme data were collected preoperatively and 6 and 12 months postoperatively. RESULTS: Five hundred patients (201 RYGB, 299 SG) were included. Serum enzyme abnormalities were common preoperatively, with 50.8% for elevated alanine aminotransferase (ALT), 33.0% for elevated aspartate aminotransferase (AST), 36.6% for elevated gamma-glutamyltranspeptidase (gamma-GT), 17.6% for elevated creatine kinase (CK), 15.2% for elevated lactic dehydrogenase (LDH), 9.0% for elevated adenosine deaminase (ADA), 6.2% for elevated hydroxybutyrate dehydrogenase (HBDH), and 8.4% for decreased superoxide dismutase (SOD). After RYGB and SG, the prevalence of serum ALT, AST, gamma-GT, LDH, and HBDH abnormalities reduced. The levels of ALT, AST, gamma-GT, ADA, cholinesterase (CHE), LDH, CK, and HBDH reduced significantly, while amylase and SOD levels increased. Age and preoperative gamma-GT level were independent predictors of ALT, AST, gamma-GT, and LDH change 1 year postoperatively. Preoperative ALT, AST, ALP, LDH, and HBDH levels could predict postoperative change, respectively. Gender and surgical procedure could predict postoperative ALP change. CONCLUSION: Serum enzyme abnormalities are common in bariatric surgery candidates, with reduced prevalence of abnormalities postoperatively. RYGB and SG are related with reduced ALT, AST, gamma-GT, ADA, CHE, LDH, CK, and HBDH levels, as well as increased amylase and SOD levels. |
| ESTHER : Guan_2020_Obes.Surg__ |
| PubMedSearch : Guan_2020_Obes.Surg__ |
| PubMedID: 32180113 |
Guan B, Chen Y, Chong TH, Peng J, Mak TK, Wang C, Yang J (2020)
Effect of Bariatric Surgery on Serum Enzyme Status in Obese Patients
Obes Surg
:
Guan B, Chen Y, Chong TH, Peng J, Mak TK, Wang C, Yang J (2020)
Obes Surg
: