Guitart_1987_FEBS.Lett_219_219

Reference

Title : Botulinum neurotoxin inhibits depolarization-stimulated protein phosphorylation in pure cholinergic synaptosomes - Guitart_1987_FEBS.Lett_219_219
Author(s) : Guitart X , Egea G , Solsona C , Marsal J
Ref : FEBS Letters , 219 :219 , 1987
Abstract :

Botulinum neurotoxin, a strong blocker of acetylcholine release at peripheral cholinergic synapses, inhibits depolarization-stimulated protein phosphorylation in pure cholinergic synaptosomes isolated from the electric organ of Torpedo marmorata. Moreover, tetrodotoxin has the same effect on protein phosphorylation when cholinergic synaptosomes are depolarized by veratridine. Correlation between presynaptic protein phosphorylation and acetylcholine release is suggested by the fact that botulinum neurotoxin blocks specifically neurotransmitter release without affecting membrane depolarization and calcium fluxes in our synaptosomal preparation.

PubMedSearch : Guitart_1987_FEBS.Lett_219_219
PubMedID: 3109951

Related information

Citations formats

Guitart X, Egea G, Solsona C, Marsal J (1987)
Botulinum neurotoxin inhibits depolarization-stimulated protein phosphorylation in pure cholinergic synaptosomes
FEBS Letters 219 :219

Guitart X, Egea G, Solsona C, Marsal J (1987)
FEBS Letters 219 :219