| Title : Synthesis and evaluation of phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors - Gundisch_2004_Bioorg.Med.Chem_12_4953 |
| Author(s) : Gundisch D , Andra M , Munoz L , Cristina Tilotta M |
| Ref : Bioorganic & Medicinal Chemistry , 12 :4953 , 2004 |
|
Abstract :
Phenylcarbamate derivatives were synthesized and evaluated in radioligand binding assays for different nicotinic acetylcholine receptor (nAChR) subtypes. Carbamate derivatives bearing a pyrrolidine or piperidine moiety 8-20 exhibited much lower affinity for alpha7* nAChR than the analogues in the quinuclidine series 21-25, although the same structural elements are present. Furthermore, in contrast to the quinuclidine analogues 21-25, all (S)-pyrrolidine derivatives 8-12 and the piperidine analogues 15 and 16 exhibited higher affinities for alpha4beta2* nAChR. |
| PubMedSearch : Gundisch_2004_Bioorg.Med.Chem_12_4953 |
| PubMedID: 15336274 |
Gundisch D, Andra M, Munoz L, Cristina Tilotta M (2004)
Synthesis and evaluation of phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors
Bioorganic & Medicinal Chemistry
12 :4953
Gundisch D, Andra M, Munoz L, Cristina Tilotta M (2004)
Bioorganic & Medicinal Chemistry
12 :4953