| Title : Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin - Guo_2012_Org.Lett_14_5684 |
| Author(s) : Guo CJ , Knox BP , Chiang YM , Lo HC , Sanchez JF , Lee KH , Oakley BR , Bruno KS , Wang CC |
| Ref : Org Lett , 14 :5684 , 2012 |
|
Abstract :
Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily. |
| PubMedSearch : Guo_2012_Org.Lett_14_5684 |
| PubMedID: 23116177 |
| Gene_locus related to this paper: asptn-trt4 |
| Gene_locus | asptn-trt4 |
Guo CJ, Knox BP, Chiang YM, Lo HC, Sanchez JF, Lee KH, Oakley BR, Bruno KS, Wang CC (2012)
Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin
Org Lett
14 :5684
Guo CJ, Knox BP, Chiang YM, Lo HC, Sanchez JF, Lee KH, Oakley BR, Bruno KS, Wang CC (2012)
Org Lett
14 :5684