| Title : Application of an efficient gene targeting system linking secondary metabolites to their biosynthetic genes in Aspergillus terreus - Guo_2013_Org.Lett_15_3562 |
| Author(s) : Guo CJ , Knox BP , Sanchez JF , Chiang YM , Bruno KS , Wang CC |
| Ref : Org Lett , 15 :3562 , 2013 |
|
Abstract :
Nonribosomal peptides (NRPs) are natural products biosynthesized by NRP synthetases. A kusA-, pyrG- mutant strain of Aspergillus terreus NIH 2624 was developed that greatly facilitated the gene targeting efficiency in this organism. Application of this tool allowed us to link four major types of NRP-related secondary metabolites to their responsible genes in A. terreus. In addition, an NRP affecting melanin synthesis was also identified in this species. |
| PubMedSearch : Guo_2013_Org.Lett_15_3562 |
| PubMedID: 23841722 |
| Gene_locus related to this paper: asptn-apva , asptn-atqa , asptn-btya , aspte-mela , asptn-mela |
| Gene_locus | asptn-apva asptn-atqa asptn-btya aspte-mela asptn-mela |
Guo CJ, Knox BP, Sanchez JF, Chiang YM, Bruno KS, Wang CC (2013)
Application of an efficient gene targeting system linking secondary metabolites to their biosynthetic genes in Aspergillus terreus
Org Lett
15 :3562
Guo CJ, Knox BP, Sanchez JF, Chiang YM, Bruno KS, Wang CC (2013)
Org Lett
15 :3562