| Title : Isolation, Biosynthesis and Chemical Modifications of Rubterolones A-F: Rare Tropolone Alkaloids from Actinomadura sp. 5-2 - Guo_2017_Chemistry_23_9338 |
| Author(s) : Guo H , Benndorf R , Leichnitz D , Klassen JL , Vollmers J , Gorls H , Steinacker M , Weigel C , Dahse HM , Kaster AK , de Beer ZW , Poulsen M , Beemelmanns C |
| Ref : Chemistry , 23 :9338 , 2017 |
|
Abstract :
The discovery of six new, highly substituted tropolone alkaloids, rubterolones A-F, from Actinomadura sp. 5-2, isolated from the gut of the fungus-growing termite Macrotermes natalensis is reported. Rubterolones were identified by using fungus-bacteria challenge assays and a HRMS-based dereplication strategy, and characterised by NMR and HRMS analyses and by X-ray crystallography. Feeding experiments and subsequent chemical derivatisation led to a first library of rubterolone derivatives (A-L). Genome sequencing and comparative analyses revealed their putative biosynthetic pathway, which was supported by feeding experiments. This study highlights how gut microbes can present a prolific source of secondary metabolites. |
| PubMedSearch : Guo_2017_Chemistry_23_9338 |
| PubMedID: 28463423 |
| Gene_locus related to this paper: 9actn-a0a2p4urp7 , 9actn-a0a2p4uhl0 , 9actn-a0a2p4uq66 |
| Gene_locus | 9actn-a0a2p4urp7 9actn-a0a2p4uhl0 9actn-a0a2p4uq66 |
Guo H, Benndorf R, Leichnitz D, Klassen JL, Vollmers J, Gorls H, Steinacker M, Weigel C, Dahse HM, Kaster AK, de Beer ZW, Poulsen M, Beemelmanns C (2017)
Isolation, Biosynthesis and Chemical Modifications of Rubterolones A-F: Rare Tropolone Alkaloids from Actinomadura sp. 5-2
Chemistry
23 :9338
Guo H, Benndorf R, Leichnitz D, Klassen JL, Vollmers J, Gorls H, Steinacker M, Weigel C, Dahse HM, Kaster AK, de Beer ZW, Poulsen M, Beemelmanns C (2017)
Chemistry
23 :9338