Title : Tomenphantadenine, an unprecedented germacranolide-adenine hybrid heterodimer from the medicinal plant Elephantopus tomentosus L - Guo_2018_Fitoterapia_125_217 |
Author(s) : Guo ZK , Wang B , Cai CH , Huang SZ , Yuan JZ , Mei WL , Dai HF |
Ref : Fitoterapia , 125 :217 , 2018 |
Abstract :
An unusual adenine-substituted germacrane sesquiterpene lactone, tomenphantadenine (1), has been isolated from the whole plant of Elephantopus tomentosus L. The structure of this compound was established by comprehensive spectroscopic analysis including high resolution (HR) ESI-MS, 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data. This compound features novel hybrid pattern of germacrane sesquiterpene with adenine through C-N linkage, and a possible biosynthetic pathway for it was proposed. Compound 1 showed potent antibacterial activity against the gram-positive Staphylococcus aureus and weak acetylcholinesterase (AChE) inhibitory activity. |
PubMedSearch : Guo_2018_Fitoterapia_125_217 |
PubMedID: 29197542 |
Guo ZK, Wang B, Cai CH, Huang SZ, Yuan JZ, Mei WL, Dai HF (2018)
Tomenphantadenine, an unprecedented germacranolide-adenine hybrid heterodimer from the medicinal plant Elephantopus tomentosus L
Fitoterapia
125 :217
Guo ZK, Wang B, Cai CH, Huang SZ, Yuan JZ, Mei WL, Dai HF (2018)
Fitoterapia
125 :217