| Title : The therapeutic potential of Berberis darwinii stem-bark: quantification of berberine and in vitro evidence for Alzheimer's disease therapy - Habtemariam_2011_Nat.Prod.Commun_6_1089 |
| Author(s) : Habtemariam S |
| Ref : Nat Prod Commun , 6 :1089 , 2011 |
|
Abstract :
Berberis darwinii is native to South America but has been widely distributed in Europe and other continents following its discovery by Charles Darwin. Herewith, the therapeutic potential of stem-bark of the plant for treating Alzheimer's disease was studied using an in vitro acetylcholinesterase inhibition assay. It was found that the methanolic extract of the stem-bark was a potent inhibitor of the enzyme with an IC50 value of 1.23 +/- 0.05 microg/mL. An HPLC-based berberine quantification study revealed an astonishing 38% yield of the dried methanolic extract. |
| PubMedSearch : Habtemariam_2011_Nat.Prod.Commun_6_1089 |
| PubMedID: 21922905 |
| Inhibitor | Berberine |
Habtemariam S (2011)
The therapeutic potential of Berberis darwinii stem-bark: quantification of berberine and in vitro evidence for Alzheimer's disease therapy
Nat Prod Commun
6 :1089
Habtemariam S (2011)
Nat Prod Commun
6 :1089