| Title : Quinuclidin-2-ene-based muscarinic antagonists - Hacksell_1995_Life.Sci_56(11-12)_831 |
| Author(s) : Hacksell U , Nilsson BM , Nordvall G , Johansson G , Sundquist S , Nilvebrant L |
| Ref : Life Sciences , 56(11-12) :831 , 1995 |
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Abstract :
A series of achiral 3-heteroaryl substituted quinuclidin-2-ene derivatives and related compounds have been synthesized by facile methods. The compounds were evaluated for muscarinic and antimuscarinic properties in receptor binding studies using (-)-[3H]-QNB as the radioligand and in a functional assay using isolated guinea pig urinary bladder. 3-(2-Benzofuranyl)-quinuclidin-2-ene (15) displayed the highest M1-receptor affinity in the present series (Ki = 9.6 nM). |
| PubMedSearch : Hacksell_1995_Life.Sci_56(11-12)_831 |
| PubMedID: 10188782 |
Hacksell U, Nilsson BM, Nordvall G, Johansson G, Sundquist S, Nilvebrant L (1995)
Quinuclidin-2-ene-based muscarinic antagonists
Life Sciences
56(11-12) :831
Hacksell U, Nilsson BM, Nordvall G, Johansson G, Sundquist S, Nilvebrant L (1995)
Life Sciences
56(11-12) :831