Hacksell_1995_Life.Sci_56(11-12)_831

Reference

Title : Quinuclidin-2-ene-based muscarinic antagonists - Hacksell_1995_Life.Sci_56(11-12)_831
Author(s) : Hacksell U , Nilsson BM , Nordvall G , Johansson G , Sundquist S , Nilvebrant L
Ref : Life Sciences , 56(11-12) :831 , 1995
Abstract :

A series of achiral 3-heteroaryl substituted quinuclidin-2-ene derivatives and related compounds have been synthesized by facile methods. The compounds were evaluated for muscarinic and antimuscarinic properties in receptor binding studies using (-)-[3H]-QNB as the radioligand and in a functional assay using isolated guinea pig urinary bladder. 3-(2-Benzofuranyl)-quinuclidin-2-ene (15) displayed the highest M1-receptor affinity in the present series (Ki = 9.6 nM).

PubMedSearch : Hacksell_1995_Life.Sci_56(11-12)_831
PubMedID: 10188782

Related information

Citations formats

Hacksell U, Nilsson BM, Nordvall G, Johansson G, Sundquist S, Nilvebrant L (1995)
Quinuclidin-2-ene-based muscarinic antagonists
Life Sciences 56(11-12) :831

Hacksell U, Nilsson BM, Nordvall G, Johansson G, Sundquist S, Nilvebrant L (1995)
Life Sciences 56(11-12) :831