| Title : Back-scattering interferometry: an ultrasensitive method for the unperturbed detection of acetylcholinesterase-inhibitor interactions - Haddad_2012_Angew.Chem.Int.Ed.Engl_51_11126 |
| Author(s) : Haddad GL , Young SC , Heindel ND , Bornhop DJ , Flowers RA, 2nd |
| Ref : Angew Chem Int Ed Engl , 51 :11126 , 2012 |
|
Abstract :
A series of inhibitors of acetylcholinesterase (AChE) have been screened by back-scattering interferometry (BSI). Enzyme levels as low as 100 pM (22 000 molecules of AChE) can be detected. This method can be used to screen for mixed AChE inhibitors, agents that have shown high efficacy against Alzheimer's disease, by detecting dual-binding interactions. E=enzyme, I=inhibitor, S=substrate. |
| PubMedSearch : Haddad_2012_Angew.Chem.Int.Ed.Engl_51_11126 |
| PubMedID: 23037915 |
Haddad GL, Young SC, Heindel ND, Bornhop DJ, Flowers RA, 2nd (2012)
Back-scattering interferometry: an ultrasensitive method for the unperturbed detection of acetylcholinesterase-inhibitor interactions
Angew Chem Int Ed Engl
51 :11126
Haddad GL, Young SC, Heindel ND, Bornhop DJ, Flowers RA, 2nd (2012)
Angew Chem Int Ed Engl
51 :11126