Title : 2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV - Haffner_2005_Bioorg.Med.Chem.Lett_15_5257 |
Author(s) : Haffner CD , McDougald DL , Reister SM , Thompson BD , Conlee C , Fang J , Bass J , Lenhard JM , Croom D , Secosky-Chang MB , Tomaszek T , McConn D , Wells-Knecht K , Johnson PR |
Ref : Bioorganic & Medicinal Chemistry Lett , 15 :5257 , 2005 |
Abstract :
We report the synthesis and biological activity of a series of 2-cyano-4-fluoro-1-thiovalylpyrrolidine inhibitors of DPP-IV. Within this series, compound 19 provided a potent, selective, and orally active DPP-IV inhibitor which demonstrated a very long duration of action in both rat and dog. |
PubMedSearch : Haffner_2005_Bioorg.Med.Chem.Lett_15_5257 |
PubMedID: 16168640 |
Haffner CD, McDougald DL, Reister SM, Thompson BD, Conlee C, Fang J, Bass J, Lenhard JM, Croom D, Secosky-Chang MB, Tomaszek T, McConn D, Wells-Knecht K, Johnson PR (2005)
2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV
Bioorganic & Medicinal Chemistry Lett
15 :5257
Haffner CD, McDougald DL, Reister SM, Thompson BD, Conlee C, Fang J, Bass J, Lenhard JM, Croom D, Secosky-Chang MB, Tomaszek T, McConn D, Wells-Knecht K, Johnson PR (2005)
Bioorganic & Medicinal Chemistry Lett
15 :5257