| Title : Oxotremorine acts as a partial nicotinic agonist on cultured chick myotubes - Haggblad_1985_Acta.Pharmacol.Toxicol.(Copenh)_57_317 |
| Author(s) : Haggblad J , Eriksson H , Heilbronn E |
| Ref : Acta Pharmacologica et Toxicologica (Copenh) , 57 :317 , 1985 |
|
Abstract :
Oxotremorine, a compound widely used as a muscarinic agonist, was found to inhibit binding of 125I-alpha-bungarotoxin to chick myotube nicotinic acetylcholine receptors, IC50 = 79 +/- 5 microM. Oxotremorine also induced a d-tubocurarine sensitive influx of 86Rb in the myotubes (EC50 = 50 +/- 15 microM). Comparative ion-flux studies with carbachol suggested a partial agonist mode of action of oxotremorine. |
| PubMedSearch : Haggblad_1985_Acta.Pharmacol.Toxicol.(Copenh)_57_317 |
| PubMedID: 4090992 |
Haggblad J, Eriksson H, Heilbronn E (1985)
Oxotremorine acts as a partial nicotinic agonist on cultured chick myotubes
Acta Pharmacologica et Toxicologica (Copenh)
57 :317
Haggblad J, Eriksson H, Heilbronn E (1985)
Acta Pharmacologica et Toxicologica (Copenh)
57 :317