Title : Therapeutic potential of quinazoline derivatives for Alzheimer's disease: A comprehensive review - Haghighijoo_2021_Eur.J.Med.Chem_227_113949 |
Author(s) : Haghighijoo Z , Zamani L , Moosavi F , Emami S |
Ref : Eur Journal of Medicinal Chemistry , 227 :113949 , 2021 |
Abstract :
Quinazolines are considered as a promising class of bioactive heterocyclic compounds with broad properties. Particularly, the quinazoline scaffold has an impressive role in the design and synthesis of new CNS-active drugs. The drug-like properties and pharmacological characteristics of quinazoline could lead to different drugs with various targets. Among CNS disorders, Alzheimer's disease (AD) is a progressive neurodegenerative disorder with memory loss, cognitive decline and language dysfunction. AD is a complex and multifactorial disease therefore, the need for finding multi-target drugs against this devastative disease is urgent. A literature survey revealed that quinazoline derivatives have diverse therapeutic potential for AD as modulators/inhibitors of beta-amyloid, tau protein, cholinesterases, monoamine oxidases, and phosphodiesterases as well as other protective effects. Thus, we describe here the most relevant and recent studies about anti-AD agents with quinazoline structure which can further aid the development and discovery of new anti-AD agents. |
PubMedSearch : Haghighijoo_2021_Eur.J.Med.Chem_227_113949 |
PubMedID: 34742016 |
Haghighijoo Z, Zamani L, Moosavi F, Emami S (2021)
Therapeutic potential of quinazoline derivatives for Alzheimer's disease: A comprehensive review
Eur Journal of Medicinal Chemistry
227 :113949
Haghighijoo Z, Zamani L, Moosavi F, Emami S (2021)
Eur Journal of Medicinal Chemistry
227 :113949