| Title : Molecular mechanisms for the regulation of the expression and function of muscarinic acetylcholine receptors - Hamilton_1998_J.Physiol.Paris_92_275 |
| Author(s) : Hamilton SE , Schlador ML , McKinnon LA , Chmelar RS , Nathanson NM |
| Ref : Journal de Physiologie (Paris) , 92 :275 , 1998 |
|
Abstract :
The regulation of muscarinic acetylcholine receptor expression and function was investigated in cultured cells and in knockout mice. Muscarinic agonist exposure causes m2 receptor desensitization and sequestration and decreases the expression of cardiac potassium channels. The expression of m2 receptors in chick retina is regulated by a developmentally regulated secreted factor. Mice lacking the m1 receptor exhibit a loss of muscarinic regulation of M-current potassium channel activity and pilocarpine-induced seizures. |
| PubMedSearch : Hamilton_1998_J.Physiol.Paris_92_275 |
| PubMedID: 9789822 |
Hamilton SE, Schlador ML, McKinnon LA, Chmelar RS, Nathanson NM (1998)
Molecular mechanisms for the regulation of the expression and function of muscarinic acetylcholine receptors
Journal de Physiologie (Paris)
92 :275
Hamilton SE, Schlador ML, McKinnon LA, Chmelar RS, Nathanson NM (1998)
Journal de Physiologie (Paris)
92 :275