| Title : Alteration of cardiovascular and neuronal function in M1 knockout mice - Hamilton_2001_Life.Sci_68(22-23)_2489 |
| Author(s) : Hamilton SE , Hardouin SN , Anagnostaras SG , Murphy GG , Richmond KN , Silva AJ , Feigl EO , Nathanson NM |
| Ref : Life Sciences , 68 :2489 , 2001 |
| Abstract : We used gene targeting to generate mice lacking the M1 muscarinic acetylcholine receptor. These mice exhibit a decreased susceptibility to pilocarpine-induced seizures, loss of regulation of M-current potassium channel activity and of a specific calcium channel pathway in sympathetic neurons, a loss of the positive chronotropic and inotropic responses to the novel muscarinic agonist McN-A-343, and impaired learning in a hippocampal-dependent test of spatial memory. |
| ESTHER : Hamilton_2001_Life.Sci_68(22-23)_2489 |
| PubMedSearch : Hamilton_2001_Life.Sci_68(22-23)_2489 |
| PubMedID: 11392617 |
Hamilton SE, Hardouin SN, Anagnostaras SG, Murphy GG, Richmond KN, Silva AJ, Feigl EO, Nathanson NM (2001)
Alteration of cardiovascular and neuronal function in M1 knockout mice
Life Sciences
68 :2489
Hamilton SE, Hardouin SN, Anagnostaras SG, Murphy GG, Richmond KN, Silva AJ, Feigl EO, Nathanson NM (2001)
Life Sciences
68 :2489