| Title : Novel benzthiodiazepinones as antiherpetic agents: SAR improvement of therapeutic index by alterations of the seven-membered ring - Hamilton_2002_Bioorg.Med.Chem.Lett_12_2981 |
| Author(s) : Hamilton HW , Nishiguchi G , Hagen SE , Domagala JD , Weber PC , Gracheck S , Boulware SL , Nordby EC , Cho H , Nakamura T , Ikeda S , Watanabe W |
| Ref : Bioorganic & Medicinal Chemistry Lett , 12 :2981 , 2002 |
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Abstract :
A series of novel benzthiodiazepinones was studied as antiherpetic agents. Significant improvements in potency and therapeutic index in a viral replication assay were realized over the starting molecule. The role of stereospecific substitution on the diazepine ring and optimal nitrogen substitution were investigated. |
| PubMedSearch : Hamilton_2002_Bioorg.Med.Chem.Lett_12_2981 |
| PubMedID: 12270188 |
Hamilton HW, Nishiguchi G, Hagen SE, Domagala JD, Weber PC, Gracheck S, Boulware SL, Nordby EC, Cho H, Nakamura T, Ikeda S, Watanabe W (2002)
Novel benzthiodiazepinones as antiherpetic agents: SAR improvement of therapeutic index by alterations of the seven-membered ring
Bioorganic & Medicinal Chemistry Lett
12 :2981
Hamilton HW, Nishiguchi G, Hagen SE, Domagala JD, Weber PC, Gracheck S, Boulware SL, Nordby EC, Cho H, Nakamura T, Ikeda S, Watanabe W (2002)
Bioorganic & Medicinal Chemistry Lett
12 :2981