| Title : The North American bullfrog draft genome provides insight into hormonal regulation of long noncoding RNA - Hammond_2017_Nat.Commun_8_1433 |
| Author(s) : Hammond SA , Warren RL , Vandervalk BP , Kucuk E , Khan H , Gibb EA , Pandoh P , Kirk H , Zhao Y , Jones M , Mungall AJ , Coope R , Pleasance S , Moore RA , Holt RA , Round JM , Ohora S , Walle BV , Veldhoen N , Helbing CC , Birol I |
| Ref : Nat Commun , 8 :1433 , 2017 |
|
Abstract :
Frogs play important ecological roles, and several species are important model organisms for scientific research. The globally distributed Ranidae (true frogs) are the largest frog family, and have substantial evolutionary distance from the model laboratory Xenopus frog species. Unfortunately, there are currently no genomic resources for the former, important group of amphibians. More widely applicable amphibian genomic data is urgently needed as more than two-thirds of known species are currently threatened or are undergoing population declines. We report a 5.8 Gbp (NG50 = 69 kbp) genome assembly of a representative North American bullfrog (Rana [Lithobates] catesbeiana). The genome contains over 22,000 predicted protein-coding genes and 6,223 candidate long noncoding RNAs (lncRNAs). RNA-Seq experiments show thyroid hormone causes widespread transcriptional change among protein-coding and putative lncRNA genes. This initial bullfrog draft genome will serve as a key resource with broad utility including amphibian research, developmental biology, and environmental research. |
| PubMedSearch : Hammond_2017_Nat.Commun_8_1433 |
| PubMedID: 29127278 |
| Gene_locus related to this paper: litct-a0a2g9rgn1 , litct-a0a2g9sm06 |
| Gene_locus | litct-a0a2g9rgn1 litct-a0a2g9sm06 |
| Gene_locus_frgt | litct-a0a2g9r8h1 litct-a0a2g9ra20 litct-a0a2g9rbz0 litct-a0a2g9rep1 litct-a0a2g9rbj0 |
Hammond SA, Warren RL, Vandervalk BP, Kucuk E, Khan H, Gibb EA, Pandoh P, Kirk H, Zhao Y, Jones M, Mungall AJ, Coope R, Pleasance S, Moore RA, Holt RA, Round JM, Ohora S, Walle BV, Veldhoen N, Helbing CC, Birol I (2017)
The North American bullfrog draft genome provides insight into hormonal regulation of long noncoding RNA
Nat Commun
8 :1433
Hammond SA, Warren RL, Vandervalk BP, Kucuk E, Khan H, Gibb EA, Pandoh P, Kirk H, Zhao Y, Jones M, Mungall AJ, Coope R, Pleasance S, Moore RA, Holt RA, Round JM, Ohora S, Walle BV, Veldhoen N, Helbing CC, Birol I (2017)
Nat Commun
8 :1433