| Title : Chemoenzymatic synthesis of rivastigmine via dynamic kinetic resolution as a key step - Han_2010_J.Org.Chem_75_3105 |
| Author(s) : Han K , Kim C , Park J , Kim MJ |
| Ref : J Org Chem , 75 :3105 , 2010 |
|
Abstract :
A practical and efficient procedure for the synthesis of rivastigmine was developed. This procedure includes dynamic kinetic resolution using a polymer-bound ruthenium complex and a lipase in combination as a key step. Enantiopure (-)-rivastigmine was obtained from commercially available 3'-hydroxyacetophenone via five steps in overall 57% yield. |
| PubMedSearch : Han_2010_J.Org.Chem_75_3105 |
| PubMedID: 20345141 |
Han K, Kim C, Park J, Kim MJ (2010)
Chemoenzymatic synthesis of rivastigmine via dynamic kinetic resolution as a key step
J Org Chem
75 :3105
Han K, Kim C, Park J, Kim MJ (2010)
J Org Chem
75 :3105