Hao_2011_Exp.Neurol_227_110

Reference

Title : Attenuation of CNS inflammatory responses by nicotine involves alpha7 and non-alpha7 nicotinic receptors - Hao_2011_Exp.Neurol_227_110
Author(s) : Hao J , Simard AR , Turner GH , Wu J , Whiteaker P , Lukas RJ , Shi FD
Ref : Experimental Neurology , 227 :110 , 2011
Abstract :

A considerable number of in vivo studies have demonstrated that the cholinergic system can dampen the peripheral immune response, and it is thought that the alpha7-nicotinic acetylcholine receptor (nAChR) subtype is a key mediator of this process. The goal of the present study was to determine if nicotine modulates immunological mechanisms known to be involved in the development of experimental autoimmune encephalomyelitis (EAE), a mouse model for CNS autoimmune disease, via alpha7-nAChRs. Here we show that nicotine exposure attenuates EAE severity and that this effect is largely abolished in nAChR alpha7 subunit knock-out mice. However, nicotine exposure partially retains the ability to reduce lymphocyte infiltration into the CNS, inhibit auto-reactive T cell proliferation and helper T cell cytokine production, down-regulate co-stimulatory protein expression on myeloid cells, and increase the differentiation and recruitment of regulatory T cells, even in the absence of alpha7-nAChRs. Diverse effects of nicotine on effector and regulatory T cells, as well as antigen-presenting cells, may be linked to differential expression patterns of nAChR subunits across these cell types. Taken together, our data show that although alpha7-nAChRs indeed seem to play an important role in nicotine-conferred reduction of the CNS inflammatory response and protection against EAE, other nAChR subtypes also are involved in the anti-inflammatory properties of the cholinergic system.

PubMedSearch : Hao_2011_Exp.Neurol_227_110
PubMedID: 20932827

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Citations formats

Hao J, Simard AR, Turner GH, Wu J, Whiteaker P, Lukas RJ, Shi FD (2011)
Attenuation of CNS inflammatory responses by nicotine involves alpha7 and non-alpha7 nicotinic receptors
Experimental Neurology 227 :110

Hao J, Simard AR, Turner GH, Wu J, Whiteaker P, Lukas RJ, Shi FD (2011)
Experimental Neurology 227 :110