Hatanaka_1986_Biochim.Biophys.Acta_878_440

Reference

Title : Hyperlipidemia in mast cell-deficient W\/WV mice - Hatanaka_1986_Biochim.Biophys.Acta_878_440
Author(s) : Hatanaka K , Tanishita H , Ishibashi-Ueda H , Yamamoto A
Ref : Biochimica & Biophysica Acta , 878 :440 , 1986
Abstract :

Approximately 70% of the W/WV mice lacking mast cells due to a genetic defect showed hypertriglyceridemia combined with hypercholesterolemia. Increases of various magnitudes in chylomicrons, very-low-density lipoprotein, and intermediate-density lipoprotein were observed in the plasma of W/WV mice compared to those in the plasma of congenic normal mice. The increase in these lipoproteins was seen even in normolipidemic W/WV mice. Activities of both lipoprotein lipase and hepatic triacylglycerol lipase in the plasma after heparin injection were markedly lower in the W/WV mice than in the congenic normal mice, although activities of both lipoprotein lipase in the heart and adipose tissue and hepatic triacylglycerol lipase in the liver were not decreased. These results suggest that the W/WV mice have genetic defects in one or more of the following: secretion of both lipases from their synthesising cells, transport to the endothelium, and anchoring to the endothelial surface. Heparin deficiency in these mice may be responsible for the impairment and, thereby, may partially contribute to the hyperlipidemia.

PubMedSearch : Hatanaka_1986_Biochim.Biophys.Acta_878_440
PubMedID: 3756204

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Citations formats

Hatanaka K, Tanishita H, Ishibashi-Ueda H, Yamamoto A (1986)
Hyperlipidemia in mast cell-deficient W\/WV mice
Biochimica & Biophysica Acta 878 :440

Hatanaka K, Tanishita H, Ishibashi-Ueda H, Yamamoto A (1986)
Biochimica & Biophysica Acta 878 :440