Hayashida_2000_Genomics_66_221

Reference

Title : Construction of a physical and transcript map flanking the imprinted MEST\/PEG1 region at 7q32 - Hayashida_2000_Genomics_66_221
Author(s) : Hayashida S , Yamasaki K , Asada Y , Soeda E , Niikawa N , Kishino T
Ref : Genomics , 66 :221 , 2000
Abstract :

MEST/PEG1, a gene expressed paternally in mesodermal derivatives in early embryonic stages, is the first imprinted gene mapped to chromosome 7q32. Since imprinted genes are clustered in general at a chromosomal region, we speculated that a similar imprinted-gene cluster may exist at chromosome region 7q32 and that the functions of some such genes may contribute to the phenotype of Silver-Russell syndrome including maternal uniparental disomy for chromosome 7 (maternal UPD7). As an initial step toward the isolation of imprinted genes at 7q32, we adopted an integrated approach involving the construction of a PAC contig and ESTs mapping in the vicinity of MEST. Here, we have constructed a complete contig of PAC and BAC clones and a transcript map spanning the entire approximately 1-Mb region between D7S530 and D7S649. We developed 60 novel STSs and precisely mapped 47 genes/ESTs. This map contains a putative autistic disorder locus that has been suggested to be localized near markers D7S530 and D7S684. This integrated physical and transcript map provides a valuable resource for identification of an imprinted gene(s) in this region as well as a candidate gene(s) for autistic disorder.

PubMedSearch : Hayashida_2000_Genomics_66_221
PubMedID: 10860668

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Citations formats

Hayashida S, Yamasaki K, Asada Y, Soeda E, Niikawa N, Kishino T (2000)
Construction of a physical and transcript map flanking the imprinted MEST\/PEG1 region at 7q32
Genomics 66 :221

Hayashida S, Yamasaki K, Asada Y, Soeda E, Niikawa N, Kishino T (2000)
Genomics 66 :221