| Title : Preservation of acetylcholine muscarinic M2 receptor G-protein interactions in the neocortex of patients with Alzheimer's disease - Hernandez-Hernandez_1995_Neurosci.Lett_186_57 |
| Author(s) : Hernandez-Hernandez A , Adem A , Ravid R , Cowburn RF |
| Ref : Neuroscience Letters , 186 :57 , 1995 |
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Abstract :
The efficacy of acetylcholine muscarinic M2 receptor-G protein coupling was investigated in Alzheimer's disease and control neocortical membranes by measuring the effects of MgCl2 and 5'-guanylylimidodiphosphate (Gpp[NH]p) on high-affinity [3H]oxotremorine-M ([3H]OXO-M) binding. MgCl2 gave similar enhancements of [3H]OXO-M binding in Alzheimer's disease and control occipital cortex. In contrast, MgCl2 enhanced [3H]OXO-M binding was significantly higher in Alzheimer's disease superior temporal cortex, compared to controls. MgCl2 enhanced [3H]OXO-M binding in both the occipital and temporal cortices of the Alzheimer's disease cases was reversed to control levels by Gpp[NH]p. It is concluded that the number of high-affinity muscarinic M2 sites is increased in Alzheimer's disease superior temporal, but not occipital, cortex and that M2 sites in both regions maintain an efficient G-protein coupling. |
| PubMedSearch : Hernandez-Hernandez_1995_Neurosci.Lett_186_57 |
| PubMedID: 7783950 |
Hernandez-Hernandez A, Adem A, Ravid R, Cowburn RF (1995)
Preservation of acetylcholine muscarinic M2 receptor G-protein interactions in the neocortex of patients with Alzheimer's disease
Neuroscience Letters
186 :57
Hernandez-Hernandez A, Adem A, Ravid R, Cowburn RF (1995)
Neuroscience Letters
186 :57