| Title : Increased intramuscular nerve branching and inhibition of programmed cell death of chick embryo motoneurons by immunoglobulins from patients with motoneuron disease - Hernandez_2010_J.Neuroimmunol_229_157 |
| Author(s) : Hernandez S , Texido L , Caldero J , Ciutat D , Piedrafita L , Casanovas A , Blasi J , Solsona C , Povedano M , Rojas R , Illa I , Caress J , Prevette D , Oppenheim RW , Milligan C , Esquerda JE |
| Ref : Journal of Neuroimmunology , 229 :157 , 2010 |
|
Abstract :
Massive programmed cell death (PCD) of developing chick embryo motoneurons (MNs) occurs in a well defined temporal and spatial sequence between embryonic day (E) 6 and E10. We have found that, when administered in ovo, either circulating immunoglobulins G (IgGs) or cerebrospinal fluid from patients with MN disease can rescue a significant number of chick embryo MNs from normally occurring PCD. An increase of branching of intramuscular nerves was also observed that may account for the rescuing effects of pathologic IgGs. Proteomic analysis and further analysis by ELISA indicated that these effects may be mediated by the interaction of circulating human immunoglobulins with proteins of the semaphorin family. |
| PubMedSearch : Hernandez_2010_J.Neuroimmunol_229_157 |
| PubMedID: 20800908 |
Hernandez S, Texido L, Caldero J, Ciutat D, Piedrafita L, Casanovas A, Blasi J, Solsona C, Povedano M, Rojas R, Illa I, Caress J, Prevette D, Oppenheim RW, Milligan C, Esquerda JE (2010)
Increased intramuscular nerve branching and inhibition of programmed cell death of chick embryo motoneurons by immunoglobulins from patients with motoneuron disease
Journal of Neuroimmunology
229 :157
Hernandez S, Texido L, Caldero J, Ciutat D, Piedrafita L, Casanovas A, Blasi J, Solsona C, Povedano M, Rojas R, Illa I, Caress J, Prevette D, Oppenheim RW, Milligan C, Esquerda JE (2010)
Journal of Neuroimmunology
229 :157