| Title : Sieboldine A, a novel tetracyclic alkaloid from Lycopodium sieboldii, inhibiting acetylcholinesterase - Hirasawa_2003_Org.Lett_5_3991 |
| Author(s) : Hirasawa Y , Morita H , Shiro M , Kobayashi J |
| Ref : Org Lett , 5 :3991 , 2003 |
|
Abstract :
[structure: see text] A novel Lycopodium alkaloid with an unprecedented fused-tetracyclic ring system consisting of an aza-cyclononane ring having a N-hydroxy group, a cyclohexanone, a cyclopentanone, and a tetrahydrofuran ring, sieboldine A (1), was isolated from the club moss Lycopodium sieboldii. The structure and relative stereochemistry were elucidated on the basis of 2D NMR data and X-ray analysis. Sieboldine A (1) exhibited a potent inhibitory activity against acetylcholinesterase and modest cytotoxicity. |
| PubMedSearch : Hirasawa_2003_Org.Lett_5_3991 |
| PubMedID: 14535761 |
Hirasawa Y, Morita H, Shiro M, Kobayashi J (2003)
Sieboldine A, a novel tetracyclic alkaloid from Lycopodium sieboldii, inhibiting acetylcholinesterase
Org Lett
5 :3991
Hirasawa Y, Morita H, Shiro M, Kobayashi J (2003)
Org Lett
5 :3991