| Title : Hupercumines A and B, Lycopodium Alkaloids from Huperzia cunninghamioides, Inhibiting Acetylcholinesterase - Hirasawa_2018_Org.Lett_20_1384 |
| Author(s) : Hirasawa Y , Mitsui C , Uchiyama N , Hakamatsuka T , Morita H |
| Ref : Org Lett , 20 :1384 , 2018 |
|
Abstract :
A novel class of C38N4 Lycopodium alkaloid, hupercumine A (1), consisting of two octahydroquinolines, a decahydroquinoline, and a piperidine, and a new C27N3-type alkaloid, hupercumine B (2), were isolated from Huperzia cunninghamioides (Hayata) Holub. The structures and absolute configurations of 1 and 2 were elucidated on the basis of spectroscopic data, chemical means, and biogenetic point of view. Hupercumines A (1) and B (2) showed moderate inhibitory activity against acetylcholinesterase. |
| PubMedSearch : Hirasawa_2018_Org.Lett_20_1384 |
| PubMedID: 29431448 |
Hirasawa Y, Mitsui C, Uchiyama N, Hakamatsuka T, Morita H (2018)
Hupercumines A and B, Lycopodium Alkaloids from Huperzia cunninghamioides, Inhibiting Acetylcholinesterase
Org Lett
20 :1384
Hirasawa Y, Mitsui C, Uchiyama N, Hakamatsuka T, Morita H (2018)
Org Lett
20 :1384