| Title : Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. II. Chemistry and structure elucidation - Hochuli_1987_J.Antibiot.(Tokyo)_40_1086 |
| Author(s) : Hochuli E , Kupfer E , Maurer R , Meister W , Mercadal Y , Schmidt K |
| Ref : J Antibiot (Tokyo) , 40 :1086 , 1987 |
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Abstract :
The structure of a new pancreatic lipase inhibitor, lipstatin, produced by Streptomyces toxytricini was determined as (2S,3S,5S,7Z,10Z)-5-[(S)-2-formamido-4-methylpentanoyloxy ]-2-hexyl-3- hydroxy-7,10-hexadecadienoic lactone by spectroscopic and chemical methods. Structurally lipstatin is closely related to the known esterase inhibitor esterastin. It contains a N-formyl-L-leucine side chain instead of the N-acetyl-L-asparagine in esterastin. |
| PubMedSearch : Hochuli_1987_J.Antibiot.(Tokyo)_40_1086 |
| PubMedID: 3680019 |
Hochuli E, Kupfer E, Maurer R, Meister W, Mercadal Y, Schmidt K (1987)
Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. II. Chemistry and structure elucidation
J Antibiot (Tokyo)
40 :1086
Hochuli E, Kupfer E, Maurer R, Meister W, Mercadal Y, Schmidt K (1987)
J Antibiot (Tokyo)
40 :1086