Hodges_1990_Pharmacol.Biochem.Behav_36_291

Reference

Title : Low dose tetrahydroaminoacridine (THA) improves cognitive function but does not affect brain acetylcholine in rats - Hodges_1990_Pharmacol.Biochem.Behav_36_291
Author(s) : Hodges H , Ribeiro AM , Gray JA , Marchbanks RM
Ref : Pharmacol Biochem Behav , 36 :291 , 1990
Abstract :

Eight days of treatment with two low doses of tetrahydroaminoacridine (THA), given once daily, substantially improved radial maze performance in two groups of rats which showed persistent deficits either after ibotenic acid lesions at the source of forebrain cholinergic projections, or after 28 weeks treatment with alcohol (20% v/v) in drinking water. However, in immature, aged or aged and alcohol-treated rats, acetylcholine content was not significantly affected in any of the brain areas measured, even though the treatment regime had proved behaviourally effective. Inhibition of brain acetylcholinesterase activity was only marginally increased by this treatment regime. Thus, if THA influences behaviour by enhancing cholinergic transmission, its effects do not appear to be related to its activity as a cholinesterase inhibitor, and alternative mechanisms of action should be investigated.

PubMedSearch : Hodges_1990_Pharmacol.Biochem.Behav_36_291
PubMedID: 2356203

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Citations formats

Hodges H, Ribeiro AM, Gray JA, Marchbanks RM (1990)
Low dose tetrahydroaminoacridine (THA) improves cognitive function but does not affect brain acetylcholine in rats
Pharmacol Biochem Behav 36 :291

Hodges H, Ribeiro AM, Gray JA, Marchbanks RM (1990)
Pharmacol Biochem Behav 36 :291