| Title : Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives - Hogenauer_2001_Bioorg.Med.Chem.Lett_11_2627 |
| Author(s) : Hogenauer K , Baumann K , Enz A , Mulzer J |
| Ref : Bioorganic & Medicinal Chemistry Lett , 11 :2627 , 2001 |
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Abstract :
(E)- and (Z)-5-Desamino huperzine A derivatives have been synthesized using a new synthetic strategy towards the huperzine A skeleton. These derivatives showed AChE inhibition constants in the low micromolar range and thus display better activity than all previously synthesized C5 derivatives. |
| PubMedSearch : Hogenauer_2001_Bioorg.Med.Chem.Lett_11_2627 |
| PubMedID: 11551765 |
Hogenauer K, Baumann K, Enz A, Mulzer J (2001)
Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives
Bioorganic & Medicinal Chemistry Lett
11 :2627
Hogenauer K, Baumann K, Enz A, Mulzer J (2001)
Bioorganic & Medicinal Chemistry Lett
11 :2627