| Title : Structure and biosynthesis of the antibiotic bottromycin D - Hou_2012_Org.Lett_14_5050 |
| Author(s) : Hou Y , Tianero MD , Kwan JC , Wyche TP , Michel CR , Ellis GA , Vazquez-Rivera E , Braun DR , Rose WE , Schmidt EW , Bugni TS |
| Ref : Org Lett , 14 :5050 , 2012 |
|
Abstract :
Drug resistant infectious diseases are quickly becoming a global health crisis. While Streptomyces spp. have been a major source of antibiotics over the past 50 years, efficient methods are needed to identify new antibiotics and greatly improve the rate of discovery. LCMS-based metabolomics were applied to analyze extracts of 50 Streptomyes spp. Using this methodology, we discovered bottromycin D and used whole genome sequencing to determine its biosynthesis by a ribosomal pathway. |
| PubMedSearch : Hou_2012_Org.Lett_14_5050 |
| PubMedID: 22984777 |
| Gene_locus related to this paper: 9actn-k4jvv8 |
| Gene_locus | 9actn-k4jvv8 |
Hou Y, Tianero MD, Kwan JC, Wyche TP, Michel CR, Ellis GA, Vazquez-Rivera E, Braun DR, Rose WE, Schmidt EW, Bugni TS (2012)
Structure and biosynthesis of the antibiotic bottromycin D
Org Lett
14 :5050
Hou Y, Tianero MD, Kwan JC, Wyche TP, Michel CR, Ellis GA, Vazquez-Rivera E, Braun DR, Rose WE, Schmidt EW, Bugni TS (2012)
Org Lett
14 :5050