Howe_2007_Eur.J.Pharmacol_577_87

Reference

Title : Dizocilpine-induced accuracy deficits in a visual signal detection task are not present following D-cycloserine administration in rats - Howe_2007_Eur.J.Pharmacol_577_87
Author(s) : Howe WM , Burk JA
Ref : European Journal of Pharmacology , 577 :87 , 2007
Abstract :

The N-methyl-D-aspartate (NMDA) receptor system is thought to be underactive in schizophrenia which may contribute to attentional dysfunction in this disease. In a visual signal detection task that required discrimination of signaled-trials from trials with no signal, the NMDA receptor antagonist, dizocilpine (0.05 mg/kg), increased errors on non-signal trials. Co-administration of dizocilpine and 10.0 mg/kg D-cycloserine, a co-agonist at the glycine site on the NMDA receptor, significantly decreased the error rate on non-signal trials compared to dizocilpine alone. These results suggest that drugs targeting the glycine site may be beneficial for attenuating attentional deficits associated with an underactive NMDA receptor system.

PubMedSearch : Howe_2007_Eur.J.Pharmacol_577_87
PubMedID: 17900560

Related information

Citations formats

Howe WM, Burk JA (2007)
Dizocilpine-induced accuracy deficits in a visual signal detection task are not present following D-cycloserine administration in rats
European Journal of Pharmacology 577 :87

Howe WM, Burk JA (2007)
European Journal of Pharmacology 577 :87