| Title : Ethylcholine mustard aziridinium ion (AF64A) impairs cholinergic neuromuscular transmission in the guinea-pig ileum and urinary bladder, and cholinergic neuromodulation in the enteric nervous system of the guinea-pig distal colon - Hoyle_1986_Gen.Pharmacol_17_543 |
| Author(s) : Hoyle CH , Moss HE , Burnstock G |
| Ref : General Pharmacology , 17 :543 , 1986 |
|
Abstract :
AF64A was examined for its ability to impair cholinergic neurotransmission in the autonomic nervous system. In the guinea-pig ileum AF64A impaired cholinergic neuromuscular transmission. In the guinea-pig urinary bladder AF64A selectivity impaired the cholinergic but not the purinergic component of neuromuscular transmission. In the guinea-pig colon circular muscle AF64A impaired cholinergic neuromodulation of the inhibitory transmission but not the inhibitory transmission itself. The nature of impairment of cholinergic transmission by AF64A is discussed. |
| PubMedSearch : Hoyle_1986_Gen.Pharmacol_17_543 |
| PubMedID: 3023171 |
Hoyle CH, Moss HE, Burnstock G (1986)
Ethylcholine mustard aziridinium ion (AF64A) impairs cholinergic neuromuscular transmission in the guinea-pig ileum and urinary bladder, and cholinergic neuromodulation in the enteric nervous system of the guinea-pig distal colon
General Pharmacology
17 :543
Hoyle CH, Moss HE, Burnstock G (1986)
General Pharmacology
17 :543