| Title : Multiple reactive immunization towards the hydrolysis of organophosphorus nerve agents: hapten design and synthesis - Huang_2001_Bioorg.Med.Chem_9_3185 |
| Author(s) : Huang H , Han WG , Noodleman L , Grynszpan F |
| Ref : Bioorganic & Medicinal Chemistry , 9 :3185 , 2001 |
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Abstract :
We designed and synthesized a series of haptens to elicit catalytic antibodies with phosphatase activity against nerve agents. The design is based on the novel concept of multiple reactive immunization which aims to afford two or more catalytic residues within the antibody's binding cleft. The haptens showed the desired reactivity in vitro and were submitted for immunization. |
| PubMedSearch : Huang_2001_Bioorg.Med.Chem_9_3185 |
| PubMedID: 11711294 |
Huang H, Han WG, Noodleman L, Grynszpan F (2001)
Multiple reactive immunization towards the hydrolysis of organophosphorus nerve agents: hapten design and synthesis
Bioorganic & Medicinal Chemistry
9 :3185
Huang H, Han WG, Noodleman L, Grynszpan F (2001)
Bioorganic & Medicinal Chemistry
9 :3185