| Title : A New Anti-acetylcholinesterase alpha-Pyrone Meroterpene, Arigsugacin I, from Mangrove Endophytic Fungus Penicillium sp. sk5GW1L of Kandelia candel - Huang_2013_Planta.Med_79_1572 |
| Author(s) : Huang X , Sun X , Ding B , Lin M , Liu L , Huang H , She Z |
| Ref : Planta Med , 79 :1572 , 2013 |
|
Abstract :
Arigsugacin I (1), a new alpha-pyrone meroterpene, along with two known compounds, arigsugacins F (2) and territrem B (3), were isolated from the mangrove endophytic fungus Penicillium sp. sk5GW1L from Kandelia candel. Their structures were identified through mass spectrometry and NMR experiments, and the absolute configuration of compound 1 was further confirmed by low-temperature (100 K) single crystal X-ray diffraction with Cu Kalpha radiation. The absolute configuration of compound 2 was first reported by using X-ray copper radiation. Compounds 1-3 showed inhibitory activities against acetylcholinesterase with IC50 values of 0.64 +/- 0.08 microM, 0.37 +/- 0.11 microM, and 7.03 +/- 0.20 nM, respectively. |
| PubMedSearch : Huang_2013_Planta.Med_79_1572 |
| PubMedID: 24081685 |
Huang X, Sun X, Ding B, Lin M, Liu L, Huang H, She Z (2013)
A New Anti-acetylcholinesterase alpha-Pyrone Meroterpene, Arigsugacin I, from Mangrove Endophytic Fungus Penicillium sp. sk5GW1L of Kandelia candel
Planta Med
79 :1572
Huang X, Sun X, Ding B, Lin M, Liu L, Huang H, She Z (2013)
Planta Med
79 :1572