| Title : Nose-to-brain delivery of drug nanocrystals by using Ca(2+) responsive deacetylated gellan gum based in situ-nanogel - Huang_2020_Int.J.Pharm__120182 |
| Author(s) : Huang G , Xie J , Shuai S , Wei S , Chen Y , Guan Z , Zheng Q , Yue P , Wang C |
| Ref : Int J Pharm , :120182 , 2020 |
| Abstract : The objective of this study is to use a carbohydrate polymer deacetylated gellan gum (DGG) as matrix to design nanocrystals based intranasal in situ gel (IG) for nose-to -brain delivery of drug. The harmine nanocrystals (HAR-NC) as model drug were prepared by coupling homogenization and spray-drying technology. The HAR-NC was redispersed in the(DGG)solutions and formed the ionic-triggered harmine nanocrystals based in situ gel(HAR-NC-IG). The crystal state of HAR remained unchanged during the homogenization and spray-drying. And the HAR-NC-IG with 0.5% DGG exhibited excellent in situ-gelation ability, water retention property and in vitro release behavior. The bioavailability in brain of intranasal HAR-NC-IG were 25-fold higher than that of oral HAR-NC, which could be attributed to nanosizing effect of HAR-NC and bioadhesive property of DGG triggered by nasal fluid. And the HAR-NC-IG could significantly inhibit the expression of acetylcholinesterase (AchE) and increase the content of acetylcholin (ACh) in brain compared with those of reference formulations (p <0.01). The DGG based nanocrystals-in situ gel was a promising carrier for nose-to-brain delivery of poorly soluble drug, which could prolong the residence time and improve the bioavailability of poorly soluble drugs in brain. |
| ESTHER : Huang_2020_Int.J.Pharm__120182 |
| PubMedSearch : Huang_2020_Int.J.Pharm__120182 |
| PubMedID: 33346126 |
Huang G, Xie J, Shuai S, Wei S, Chen Y, Guan Z, Zheng Q, Yue P, Wang C (2020)
Nose-to-brain delivery of drug nanocrystals by using Ca(2+) responsive deacetylated gellan gum based in situ-nanogel
Int J Pharm
:120182
Huang G, Xie J, Shuai S, Wei S, Chen Y, Guan Z, Zheng Q, Yue P, Wang C (2020)
Int J Pharm
:120182